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Kote Avdalyan – Govand. The forward represents nucleotides – of the M-F region in the positive sense and the reverse represents nucleotides – of the H-L region in the negative sense. N-linked glycosylation sites and cysteine residues The F protein of Asian isolates had seven potential glycosylation sites Fig. A hypothesis for changes. Support Center Support Center. The phylogenetic analysis of F gene gives clear picture for the H gene identical CDV strains and the signal peptide region gives a remarkable differentiation between Asia 1 and Asia 2 isolates. Koma Kurdistan – Govend.
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Metallica – Nothing Else Matters. Strains 50Con and 50Cbl had the same amino acids at positions and as Onderstepoort strain. Genetic diversity of the attachment H protein gene of current field isolates of canine distemper virus. In addition to the four conserved N-linked glycosylation sites, three were found only in Asia 1 isolates.
Growth profiles of recent canine distemper isolates on Vero cells expressing canine signaling lymphocyte activation molecule SLAM Journal of Comparative Pathology. Molecular identification of a recent type of canine distemper virus in Japan by restriction fragment length polymorphism. Comparative analyses of canine distemper viral isolates from clinical cases of canine distemper in vaccinated dogs.
Serageldeen Sultan received financial support in the form of a PhD degree scholarship from the Egyptian government. Heterogeneity within the hemagglutinin genes of canine distemper virus CDV strains detected in Italy.
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Alignment of deduced amino acid sequences of F genes naatya CDV strains. N-glycans on Nipah virus fusion protein protect against neutralization but reduce membrane fusion and viral entry. Signal peptide and helical bundle domains of virulent canine distemper virus fusion protein restrict fusogenicity. Author information Article notes Copyright and License information Disclaimer.
The Journal of Veterinary Medical Science.
Our finding of different glycosylation sites of the F proteins suggested that these F proteins have different characters. At its C-terminus, a hydrophobic trans-membrane domain TM anchors the protein in the membrane leaving a short cytoplasmic tail residues. Virus membrane fusion proteins: The identification of frequent variations in the fusion protein of canine jataya virus.
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In this study the phylogenetic characterization of F as well as H protein genes among Asian isolates of CDV was carried out to know the genetic variations of F genes. Numbering starts at the first methionine residue of the Onderstepoort strain. Materials and naraya Cells and Viruses Vero. Govinda – Raga ft Anand Krishnamurthy.
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Fusion protein gene nucleotide sequence similarities, shared antigenic sites and phylogenetic analysis suggest that phocid distemper virus type 2 and canine distemper virus belong to the same virus entity. Phylogenetic characterization of canine distemper viruses detected in naturally infected dogs natayw North America. Amino-terminal precursor sequence modulates canine distemper virus fusion protein function.
Gubin – Various mp3 track. So, the frequent variation observed in signal peptide region among Asian isolates may account for viral pathogenesis. The primers used were as follows: Strains Th12 and Ac96I were differentiated from other Asia 1 strains by the F protein glycosylation sites. A hypothesis for changes. Previous studies have suggested that translation of F protein starts at the first initiation codon, AUG1, or at the second codon, AUG61, that locates in the signal peptide region [ 223 ].
Atmarama das – Gopinatha. These seven glycosylation sites are shared by Taiwanese field isolates [ 22 ].
Alignment of the nucleotide sequences of different CDV field isolates and Onderstepoort strain from natqya to upstream of the usual initiation codon of F gene ORF start from nt showing the extra 27 nucleotides and their deduced 9 amino acids in Asia 2 isolates.